Zelfina Skin Cream You can't get rid of wrinkles right away even with the most effective treatment. You have to be very disciplined and religious. In other words, you should follow instructions and you should apply these creams to your wrinkles only when you are supposed to. If the duration of the treatment would last for a month, do it. Chances are; your wrinkles will not go away if you were too impatient to go on a strict regimen. If your wrinkles are not removed after 2 months, change your cream. Understand that the effects of anti-wrinkle creams vary depending on your age and skin type. If you still have doubts about one product, talk to your dermatologist. He can recommend a brand that is right for you.